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Viagra (sildenafil, sildenafil) 100 mg, at 50 mg or 100 mg helped approximately 4 out of 5 men get and keep erections hard enough for sex.

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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction

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  • Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered
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Related webpage If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: May interact with some medications including certain antibiotics and antifungals, herbal remedies, HIV medicines and drugs used in the treatment of high blood pressure or prostate disorders.

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Grapefruit juice may also increase the side effects of Viagra. Viagra belongs to the class of medicines known as PDE-5 inhibitors.

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Sildenafil and other Phosphodiesterase type 5 PDE5 drugs work by increasing blood flow to the penis. It works within 30 to 60 minutes, but may be taken up to four hours before sexual activity.

If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result with hyundaivrakoviste.cz. The mean age of the study group was Also, how easy the turn loose sagging skin or overnight canadian viagra.

Upsides Viagra is approved to treat erectile dysfunction EDalso known as impotence, in men. Common 250 mg viagra that may interact with Viagra include: Though the mg effects do not last longer than a lower dosage, the higher concentration does have a more profound effect. Speak to your doctor about how drug interactions should be managed.

Some people taking Viagra have had bleeding events; however, it has not been established if this is actually related to Viagra use. The objectives of this study were to evaluate the efficacy and tolerability of high dose sildenafil as a salvage therapy for patients refractory to the maximum recommended dose of sildenafil.

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It is not possible to determine whether these events are related directly to these factors or to other factors. After chronic dosing of 80 mg three times a day sildenafil to patients with PAH, lesser reductions than above in systolic and diastolic blood pressures were observed a decrease in both of 2 mmHg. Sildenafil had no effect on ritonavir pharmacokinetics.


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When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. CYP3A4 inducers including bosentan Concomitant administration of potent CYP3A inducers is expected to cause substantial decreases in plasma levels of sildenafil.


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Call your doctor immediately if you experience dizziness or feel nauseous during sexual activity, or develop pain, numbness, tingling in your chest, arms, neck, or jaw. Taking these substances together can cause a sudden and dangerous drop in blood pressure. This enzyme breaks down cGMP, a substance that induces smooth muscles to relax.


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